Leptin inhibits food intake without affecting brain NOx levels in food-deprived mice.
نویسندگان
چکیده
Effects of leptin on food intake and nitric oxide (NO) metabolites (nitrite and nitrate, NOx) levels of brain were investigated in mice. Leptin dose-dependently decreased milk intake in food-deprived mice. Administration of leptin at a dose of 1 mg/kg, which induces an apparent hypophagia, did not affect NOx levels in the hypothalamus and frontal cortex. These results suggest that leptin reduces food intake in food-deprived mice without altering NO production in the hypothalamus, which plays an important role in regulation of feeding.
منابع مشابه
Food hoarding is increased by food deprivation and decreased by leptin treatment in Syrian hamsters.
Compensatory increases in food intake are commonly observed after a period of food deprivation in many species, including laboratory rats and mice. Thus it is interesting that Syrian hamsters fail to increase food intake after a period of food deprivation, despite a fall in plasma leptin concentrations similar to those seen in food-deprived rats and mice. In previous laboratory studies, food-de...
متن کاملLeptin inhibits food-deprivation-induced increases in food intake and food hoarding.
Food deprivation stimulates foraging and hoarding and to a much lesser extent, food intake in Siberian hamsters. Leptin, the anorexigenic hormone secreted primarily from adipocytes, may act in the periphery, the brain, or both to inhibit these ingestive behaviors. Therefore, we tested whether leptin given either intracerebroventricularly or intraperitoneally, would block food deprivation-induce...
متن کاملCALL FOR PAPERS Neural Integration of Peripheral Signals Implicated in the Control of Energy Homeostasis and Metabolism Leptin inhibits food-deprivation-induced increases in food intake and food hoarding
Keen-Rhinehart E, Bartness TJ. Leptin inhibits food-deprivation-induced increases in food intake and food hoarding. Am J Physiol Regul Integr Comp Physiol 295: R1737–R1746, 2008. First published October 1, 2008; doi:10.1152/ajpregu.90512.2008.—Food deprivation stimulates foraging and hoarding and to a much lesser extent, food intake in Siberian hamsters. Leptin, the anorexigenic hormone secrete...
متن کاملPeptides that Regulate Food Intake Food hoarding is increased by food deprivation and decreased by leptin treatment in Syrian hamsters
Buckley, Carolyn A., and Jill E. Schneider. Food hoarding is increased by food deprivation and decreased by leptin treatment in Syrian hamsters. Am J Physiol Regul Integr Comp Physiol 285: R1021–R1029, 2003. First published May 1, 2003; 10.1152/ajpregu.00488.2002.—Compensatory increases in food intake are commonly observed after a period of food deprivation in many species, including laboratory...
متن کاملCentral effect of histamine and antihistamines on food intake in freely feeding and food-deprived rabbits
Several lines of evidence suggest that brain histamine may be involved in the central control of food intake. The effect of histamine on feeding is mediated through three kinds of receptors (H1, H2, and H3). The present study was designed to investigate the effect of intracerebroventricular injection of histamine, promethazine (H1 antagonist) and ranitidine (H2 antagonist) on food intake of fre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biological & pharmaceutical bulletin
دوره 26 1 شماره
صفحات -
تاریخ انتشار 2003